NDLI: 2′-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway

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2′-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway

Content Provider	MDPI
Author	Wang, Jin Hu, Jia-Qiang Song, Yu-Jie Yin, Jia Wang, Yuan-Yi-Fei Peng, Bo Zhang, Bo-Wei Liu, Jing-Min Dong, Lu Wang, Shuo
Copyright Year	2022
Description	The imbalance of reactive oxygen species is the main cause in aging, accompanied by oxidative stress. As the most abundant in human milk oligosaccharides (HMOs), 2′-Fucosyllactose (2′-FL) has been confirmed to have great properties in immunity regulation and anti-inflammatory. The research on 2′-FL is focused on infants currently, while there is no related report of 2′-FL for the elderly. A d-galactose-induced accelerated aging model was established to explore the protective effect of 2′-FL on the intestines and brain in mice. In this study, 2′-FL significantly reduced oxidative stress damage and inflammation in the intestines of aging mice, potentially by regulating the sirtuin1 (SIRT1)-related and nuclear factor E2-related factor 2 (Nrf2) pathways. In addition, 2′-FL significantly improved the gut mucosal barrier function and increased the content of short-chain fatty acids (SCFAs) in the intestine. The gut microbiota analysis indicated that 2′-FL mainly increased the abundance of probiotics like Akkermansia in aging mice. Moreover, 2′-FL significantly inhibited apoptosis in the brains of aging mice, also increasing the expression of SIRT1. These findings provided a basis for learning the benefits of 2′-FL in the aging process.
Starting Page	151
e-ISSN	23048158
DOI	10.3390/foods11020151
Journal	Foods
Issue Number	2
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-01-07
Access Restriction	Open
Subject Keyword	Foods Gerontology 2′-fucosyllactose Aging Sirt1 Gut Microbiota
Content Type	Text
Resource Type	Article

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