NDLI: Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages

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Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages

Content Provider	MDPI
Author	Han, Eui-Jeong Jayawardena, Thilina U. Jang, Jae-Hyuk Fernando, Ilekuttige Priyan Shanura Jee, Youngheun Jeon, You-Jin Lee, Dae-Sung Lee, Jeong-Min Yim, Mi-Jin Wang, Lei Kim, Hyun-Soo Ahn, Ginnae
Copyright Year	2021
Description	In this study, we isolated sargachromenol (SC) from Sargassum horneri and evaluated its anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. SC did not show cytotoxicity at all concentrations and effectively increased the cell viability by reducing the nitric oxide (NO) and intracellular reactive oxygen species (ROS) production in LPS-stimulated RAW 264.7 macrophages. In addition, SC decreased the mRNA expression levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS and COX-2). Moreover, SC suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and mitogen-activated protein kinase (MAPK) signaling, whereas activated the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling in LPS-stimulated RAW 264.7 macrophages. Interestingly, the anti-inflammatory effect of SC was abolished by the inhibition of HO-1 in LPS-stimulated RAW 264.7 macrophages. According to the results, this study suggests that the antioxidant capacity of SC leads to its anti-inflammatory effect and it potentially may be utilized in the nutraceutical and pharmaceutical sectors.
Starting Page	497
e-ISSN	16603397
DOI	10.3390/md19090497
Journal	Marine drugs
Issue Number	9
Volume Number	19
Language	English
Publisher	MDPI
Publisher Date	2021-08-31
Access Restriction	Open
Subject Keyword	Marine drugs Marine Drugs Immunology Sargassum Horneri Sargachromenol Anti-inflammatory Effect Nrf2/ho-1 Signaling Raw 264.7 Macrophages
Content Type	Text
Resource Type	Article

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