NDLI: Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer

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Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer

Content Provider	MDPI
Author	Natalia, García-Sancha Marina, Mendiburu-Eliçabe Aurora, Gómez-Vecino Alejandro, Jiménez-Navas Manuel, Jesús Pérez-Baena Javier, Cañueto Jes, ús Pérez-Losada Corchado-Cobos, Roberto Holgado-Madruga, Marina Mao, Jian-Hua Castillo-Lluva, Sonia
Copyright Year	2022
Description	Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of these metabolic changes are located in the tumor parenchymal cells, where oncogenic mutations induce an imperative need to proliferate and cause tumor initiation and progression. Cancer cells undergo significant metabolic reorganization during disease progression that is tailored to their energy demands and fluctuating environmental conditions. Oxidative stress plays an essential role as a trigger under such conditions. These metabolic changes are the consequence of the interaction between tumor cells and stromal myofibroblasts. The metabolic changes in tumor cells include protein anabolism and the synthesis of cell membranes and nucleic acids, which all facilitate cell proliferation. They are linked to catabolism and autophagy in stromal myofibroblasts, causing the release of nutrients for the cells of the tumor parenchyma. Metabolic changes lead to an interstitium deficient in nutrients, such as glucose and amino acids, and acidification by lactic acid. Together with hypoxia, they produce functional changes in other cells of the tumor stroma, such as many immune subpopulations and endothelial cells, which lead to tumor growth. Thus, immune cells favor tissue growth through changes in immunosuppression. This review considers some of the metabolic changes described in breast cancer.
Starting Page	322
e-ISSN	20726694
DOI	10.3390/cancers14020322
Journal	Cancers
Issue Number	2
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-01-10
Access Restriction	Open
Subject Keyword	Cancers Oncology Metabolism Interstitium Glucose Lactate Hypoxia Cancer-associated Fibroblasts Macrophages
Content Type	Text
Resource Type	Article

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