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Two-Phase Dibromocyclopropanation of Unsaturated Alcohols Using Flow Chemistry
| Content Provider | MDPI |
|---|---|
| Author | Runa, Berg Østby Yngve, Stenstrøm Didriksen, Terje Antonsen, Simen Gjelseth Nicolaisen, Steinar Sollien |
| Copyright Year | 2020 |
| Description | Dibromocyclopropanations are conventionally done by addition of dibromocarbene to alkenes under phase-transfer conditions in batch reactions using a strong base (50% NaOH (aq)), vigorous stirring and long reaction times. We have shown that cyclopropanation of unsaturated alcohols can be done under ambient conditions using continuous flow chemistry with 40% (w/w) NaOH (aq) as the base. The reactions were generally rapid; the yields were comparable to yields reported in the literature for the conventional batch reaction |
| Starting Page | 2364 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules25102364 |
| Journal | Molecules |
| Issue Number | 10 |
| Volume Number | 25 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-05-19 |
| Access Restriction | Open |
| Subject Keyword | Molecules Organic Chemistry Dibromocyclopropanation Chbr3 Makosza Reaction Phase-transfer Catalysis Flow Chemistry Unsaturated Alcohols |
| Content Type | Text |
| Resource Type | Article |
