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Methods of Topical Administration of Drugs and Biological Active Substances for Dental Implants—A Narrative Review
| Content Provider | MDPI |
|---|---|
| Author | Piotr, Wychowański Anna, Starzyńska Monika, Słupecka-Ziemilska Adamska, Paulina Sobocki, Bartosz Chmielewska, Agnieszka Wysocki, Bartłomiej Alterio, Daniela Marvaso, Giulia Jereczek-Fossa, Barbara Kowalski, Jan |
| Copyright Year | 2021 |
| Description | Dental implants are, nowadays, established surgical devices for the restoration of lost teeth. Considered as an alternative for traditional prosthetic appliances, dental implants surpass them in reliability and patient feedback. Local drug delivery around the implants promotes osseointegration and reduces peri-implantitis. However, there are currently no methods of a multiple, precise topical administration of drugs to the implant area. Engineering coatings on the implants, drug application on carriers during implantation, or gingival pockets do not meet all requirements of dental surgeons. Therefore, there is a need to create porous implants and other medical devices that will allow a multiple drug delivery at a controlled dose and release profile without traumatic treatment. Due to the growing demand for the use of biologically active agents to support dental implant treatment at its various stages (implant placement, long-term use of dental superstructures, treatment of the peri-implant conditions) and due to the proven effectiveness of the topical application of pharmacological biologically active agents to the implant area, the authors would like to present a review and show the methods and devices that can be used by clinicians for local drug administration to facilitate dental implant treatment. Our review concludes that there is a need for research in the field of inventions such as new medical devices or implants with gradient solid–porous structures. These devices, in the future, will enable to perform repeatable, controllable, atraumatic, and repeatable injections of active factors that may affect the improvement of osteointegration and the longer survival of implants, as well as the treatment of peri-implantitis. |
| Starting Page | 919 |
| e-ISSN | 20796382 |
| DOI | 10.3390/antibiotics10080919 |
| Journal | Antibiotics |
| Issue Number | 8 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-28 |
| Access Restriction | Open |
| Subject Keyword | Antibiotics Dentistry and Oral Surgery Dental Implants Local Drug Delivery Dental Implant Coatings Dental Implant Surface Medical Device Dental Implant Construction Biocompatibility Osseointegration |
| Content Type | Text |
| Resource Type | Article |
