NDLI: Antioxidant and Anti-Inflammatory Activities of Cytocompatible Salvia officinalis Extracts: A Comparison between Traditional and Soxhlet Extraction

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Antioxidant and Anti-Inflammatory Activities of Cytocompatible Salvia officinalis Extracts: A Comparison between Traditional and Soxhlet Extraction

Content Provider	MDPI
Author	Vieira, Sara F. Ferreira, Helena Neves, Nuno M.
Copyright Year	2020
Description	Chronic inflammation is characterized by an overproduction of several inflammatory mediators (e.g., reactive species and interleukins -IL) that play a central role in numerous diseases. The available therapies are often associated with serious side effects and, consequently, the need for safer drugs is of utmost importance. A plant traditionally used in the treatment of inflammatory conditions is Salvia officinalis. Therefore, conventional maceration and infusion of its leaves were performed to obtain hydroethanolic (HE-T) and aqueous extracts (AE-T), respectively. Their efficacy was compared to soxhlet extracts, namely aqueous (AE-S), hydroethanolic (HE-S), and ethanolic extracts (EE-S). Thin-layer chromatography demonstrated the presence of rosmarinic acid, carnosol, and/or carnosic acid in the different extracts. Generally, soxhlet provided extracts with higher antioxidant activities than traditional extraction. Moreover, under an inflammatory scenario, EE-S were the most effective, followed by HE-S, HE-T, AE-T, and AE-S, in the reduction of IL-6 and TNF-α production. Interestingly, the extracts presented higher or similar anti-inflammatory activity than diclofenac, salicylic acid, and celecoxib. In conclusion, the extraction method and the solvents of extraction influenced the antioxidant activity, but mainly the anti-inflammatory activity of the extracts. Therefore, this natural resource can enable the development of effective treatments for oxidative stress and inflammatory diseases.
Starting Page	1157
e-ISSN	20763921
DOI	10.3390/antiox9111157
Journal	Antioxidants
Issue Number	11
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2020-11-20
Access Restriction	Open
Subject Keyword	Antioxidants Integrative and Complementary Medicine Salvia Officinalis Traditional Extraction Soxhlet Extraction Antioxidant Activity Reactive Oxygen and Nitrogen Species Anti-inflammatory Activity Cytocompatibility
Content Type	Text
Resource Type	Article

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