NDLI: Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions

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Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions

Content Provider	MDPI
Author	Lyagin, Ilya Efremenko, Elena
Copyright Year	2021
Description	Organophosphorus compounds (OPCs) are able to interact with various biological targets in living organisms, including enzymes. The binding of OPCs to enzymes does not always lead to negative consequences for the body itself, since there are a lot of natural biocatalysts that can catalyze the chemical transformations of the OPCs via hydrolysis or oxidation/reduction and thereby provide their detoxification. Some of these enzymes, their structural differences and identity, mechanisms, and specificity of catalytic action are discussed in this work, including results of computational modeling. Phylogenetic analysis of these diverse enzymes was specially realized for this review to emphasize a great area for future development(s) and applications.
Starting Page	1761
e-ISSN	14220067
DOI	10.3390/ijms22041761
Journal	International Journal of Molecular Sciences
Issue Number	4
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-02-10
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Biochemistry and Molecular Biology Organophosphorus Toxin Hydrolase Cholinesterase Paraoxonase Phosphatase Senescence Marker Protein 30 Catalysis Mechanism Active Center Docking Computational Modeling
Content Type	Text
Resource Type	Article

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