NDLI: Organic Nanoparticles Based on D-A-D Small Molecule: Self-Assembly, Photophysical Properties, and Synergistic Photodynamic/Photothermal Effects

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Organic Nanoparticles Based on D-A-D Small Molecule: Self-Assembly, Photophysical Properties, and Synergistic Photodynamic/Photothermal Effects

Content Provider	MDPI
Author	Yue, Liangliang Li, Haolan Sun, Qi Luo, Xiaogang Wu, Fengshou Zhu, Xunjin
Copyright Year	2022
Description	Cancer is one of the major diseases threatening human health. Traditional cancer treatments have notable side-effects as they can damage the immune system. Recently, phototherapy, as a potential strategy for clinical cancer therapy, has received wide attention due to its minimal invasiveness and high efficiency. Herein, a small organic molecule (PTA) with a D-A-D structure was prepared via a Sonogashira coupling reaction between the electron-withdrawing dibromo-perylenediimide and electron-donating 4-ethynyl-N,N-diphenylaniline. The amphiphilic organic molecule was then transformed into nanoparticles (PTA-NPs) through the self-assembling method. Upon laser irradiation at 635 nm, PTA-NPs displayed a high photothermal conversion efficiency (PCE = 43%) together with efficient reactive oxygen species (ROS) generation. The fluorescence images also indicated the production of ROS in cancer cells with PTA-NPs. In addition, the biocompatibility and photocytotoxicity of PTA-NPs were evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and live/dead cell co-staining test. Therefore, the as-prepared organic nanomaterials were demonstrated as promising nanomaterials for cancer phototherapy in the clinic.
Starting Page	502
e-ISSN	19961944
DOI	10.3390/ma15020502
Journal	Materials
Issue Number	2
Volume Number	15
Language	English
Publisher	MDPI
Publisher Date	2022-01-10
Access Restriction	Open
Subject Keyword	Materials Oncology Perylene Diimide Self-assembly Organic Nanomaterials Photothermal Therapy Reactive Oxygen Species
Content Type	Text
Resource Type	Article

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