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N-(2-Arylethyl)-2-methylprop-2-enamides as Versatile Reagents for Synthesis of Molecularly Imprinted Polymers
| Content Provider | MDPI |
|---|---|
| Author | Piotr, Luliński Sobiech, Monika Maciejewska, Dorota |
| Copyright Year | 2022 |
| Description | The paper describes the formation of six aromatic N-(2-arylethyl)-2-methylprop-2-enamides with various substituents in benzene ring, viz., 4-F, 4-Cl, $2,4-Cl_{2}$, 4-Br, 4-OMe, and $3,4-(OMe)_{2}$ from 2-arylethylamines and methacryloyl chloride in ethylene dichloride with high yields (46–94%). The structure of the compounds was confirmed by$ ^{1}$H NMR,$ ^{13}$C NMR, IR, and HR-MS. Those compounds were obtained to serve as functionalized templates for the fabrication of molecularly imprinted polymers followed by the hydrolysis of an amide linkage. In an exemplary experiment, the imprinted polymer was produced from N-(2-(4-bromophenyl)ethyl)-2-methylprop-2-enamide and divinylbenzene, acting as cross-linker. The hydrolysis of 2-(4-bromophenyl)ethyl residue proceeded and the characterization of material including SEM, EDS,$ ^{13}$C CP MAS NMR, and BET on various steps of preparation was carried out. The adsorption studies proved that there was a high affinity towards the target biomolecules tyramine and L-norepinephrine, with imprinting factors equal to 2.47 and 2.50, respectively, when compared to non-imprinted polymer synthesized from methacrylic acid and divinylbenzene only. |
| Starting Page | 2738 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym14132738 |
| Journal | Polymers |
| Issue Number | 13 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-07-04 |
| Access Restriction | Open |
| Subject Keyword | Polymers Analytical Chemistry N-acylation Phenethylamines Molecularly Imprinted Polymers Semi-covalent Imprinting Tyramine |
| Content Type | Text |
| Resource Type | Article |
