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Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines
| Content Provider | MDPI |
|---|---|
| Author | Diana, Noriega-Rodríguez Cristian, Torres-Alarcón Mar, ía Elvira Zúñiga-Hansen Soto-Maldonado, Carmen Pastrana-Castro, Lorenzo Weinstein-Oppenheimer, Caroline |
| Copyright Year | 2020 |
| Description | Globe artichoke (Cynara scolymus L.) is considered one of the most significant sources of phenolic antioxidants in nature. However, more than 60% of its total volume is discarded for consumption purposes, making available an abundant, inexpensive and profitable source of natural antioxidants in the discarded fractions. Polyphenolic antioxidants from a South American variety of artichoke agro-industrial discards (external bracts and stems) were obtained by mild extraction processes. Best results were achieved at 40 °C, 75% of ethanol and 10 min of reaction, obtaining 2.16 g gallic acid equivalent (GAE)/100 g of total phenolic compounds (TPC) and 55,472.34 µmol Trolox equivalent (TE)/100 g of antioxidant capacity (oxygen radical absorbance capacity (ORAC)). High-performance liquid chromatography (HPLC) analyses determined that caffeoylquinic acids comprise up to 85% of the total polyphenolic content, and only around 5% are flavonoids. Inulin content in the artichokes residues was recovered (48.4% dry weight (dw)), resulting in an extract with 28% of inulin in addition to the aforementioned antioxidant capacity. The artichoke discard extract in a concentration of 500 mg/L produced a strong decrease in Caco-2 and MCF-7 cancer cell lines viability, whereas healthy fibroblasts maintained their viability when the extract was concentrated at 1500 mg/L. These results suggest that the artichoke extract presents a good anti-proliferative potential effect on Caco-2 and MCF-7 cells. |
| Starting Page | 715 |
| e-ISSN | 22279717 |
| DOI | 10.3390/pr8060715 |
| Journal | Processes |
| Issue Number | 6 |
| Volume Number | 8 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-06-20 |
| Access Restriction | Open |
| Subject Keyword | Processes Paper and Wood Artichoke Discards Polyphenols Antioxidant Activity Inulin Caco-2 Mcf-7 |
| Content Type | Text |
| Resource Type | Article |
