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NPvis: An Interactive Visualizer of Peptidic Natural Product–MS/MS Matches
| Content Provider | MDPI |
|---|---|
| Author | Kunyavskaya, Olga Mikheenko, Alla Gurevich, Alexey |
| Copyright Year | 2022 |
| Description | Peptidic natural products (PNPs) represent a medically important class of secondary metabolites that includes antibiotics, anti-inflammatory and antitumor agents. Advances in tandem mass spectra (MS/MS) acquisition and in silico database search methods have enabled high-throughput PNP discovery. However, the resulting spectra annotations are often error-prone and their validation remains a bottleneck. Here, we present NPvis, a visualizer suitable for the evaluation of PNP–MS/MS matches. The tool interactively maps annotated spectrum peaks to the corresponding PNP fragments and allows researchers to assess the match correctness. NPvis accounts for the wide chemical diversity of PNPs that prevents the use of the existing proteomics visualizers. Moreover, NPvis works even if the exact chemical structure of the matching PNP is unknown. The tool is available online and as a standalone application. We hope that it will benefit the community by streamlining PNP data analysis and validation. |
| Starting Page | 706 |
| e-ISSN | 22181989 |
| DOI | 10.3390/metabo12080706 |
| Journal | Metabolites |
| Issue Number | 8 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-07-29 |
| Access Restriction | Open |
| Subject Keyword | Metabolites Biochemical Research Peptidic Natural Products Bioinformatics Mass Spectrometry Visualization Software |
| Content Type | Text |
| Resource Type | Article |
