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Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa
| Content Provider | MDPI |
|---|---|
| Author | O’Brien, Elizabeth Racanelli, Elysia Jfri, Abdulhadi Gefri, Amnah Litvinov, Ivan Zubarev, Andrey Savin, Evgeny Netchiporouk, Elena |
| Copyright Year | 2021 |
| Description | Background: Cutaneous squamous cell carcinoma (cSCC) is a rare complication of hidradenitis suppurativa (HS). Objectives: To conduct a systematic review and an individual patient data (IPD) meta-analysis to describe the clinical characteristics of HS patients developing cSCC and determine predictors of poor outcome. Methods: Medline/PubMed, Embase, and Web of Science were searched for studies reporting cSCC arising in patients with HS from inception to December 2019. A routine descriptive analysis, statistical hypothesis testing, and Kaplan–Meier survival curves/Cox proportional hazards regression models were performed. Results: A total of 34 case reports and series including 138 patients were included in the study. The majority of patients were males (81.6%), White (83.3%), and smokers (n = 22/27 reported) with a mean age of 53.5 years. Most patients had gluteal (87.8%), Hurley stage 3 HS (88.6%). The mean time from the diagnosis of HS to the development of cSCC was 24.7 years. Human papillomavirus was identified in 12/38 patients tested. Almost 50% of individuals had nodal metastasis and 31.3% had distant metastases. Half of the patients succumbed to their disease. Conclusions: cSCC is a rare but life-threatening complication seen in HS patients, mainly occurring in White males who are smokers with severe, long-standing gluteal HS. Regular clinical examination and biopsy of any suspicious lesions in high-risk patients should be considered. The use of HPV vaccination as a preventive and possibly curative method needs to be explored. |
| Starting Page | 1153 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13051153 |
| Journal | Cancers |
| Issue Number | 5 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-08 |
| Access Restriction | Open |
| Subject Keyword | Cancers Dermatology Hidradenitis Suppurativa Verneuil's Disease Acne Inversa Cutaneous Squamous Cell Carcinoma Marjolin Ulcer Human Papillomavirus |
| Content Type | Text |
| Resource Type | Article |
