NDLI: The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

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The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

Content Provider	MDPI
Author	Gabriel, Alves Bonafé Leite, Camila Dos Santos Santos, Juliana Carvalho Martinez, Carlos Augusto Real Ortega, Manoela Marques Ribeiro, Marcelo Lima
Copyright Year	2022
Description	Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. IBD-associated cancer develops against a background of chronic inflammation and oxidative stress, and their products contribute to cancer development and progression. Therefore, the discovery of novel drugs for the treatment of intestinal diseases is urgently needed. Licorice (Glycyrrhiza glabra) has been largely used for thousands of years in traditional Chinese medicine. Licorice and its derived compounds possess antiallergic, antibacterial, antiviral, anti-inflammatory, and antitumor effects. These pharmacological properties aid in the treatment of inflammatory diseases. In this review, we discuss the pharmacological potential of bioactive compounds derived from Licorice and addresses their anti-inflammatory and antioxidant properties. We also discuss how the mechanisms of action in these compounds can influence their effectiveness and lead to therapeutic effects on intestinal disorders.
Starting Page	4121
e-ISSN	14220067
DOI	10.3390/ijms23084121
Journal	International Journal of Molecular Sciences
Issue Number	8
Volume Number	23
Language	English
Publisher	MDPI
Publisher Date	2022-04-08
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Glycyrrhiza Glabra-derived Compounds Glycyrrhizin (g) Glycyrrhetinic Acid (ga) Dipotassium Glycyrrhizinate (dpg) Inflammation Oxidative Stress Intestinal Disorders
Content Type	Text
Resource Type	Article

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