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Surface Acoustic Wave Sensor for C-Reactive Protein Detection
| Content Provider | MDPI |
|---|---|
| Author | Jeng, Ming-Jer Sharma, Mukta Li, Ying-Chang Lu, Yi-Chen Yu, Chia-Yu Tsai, Chia-Lung Huang, Shiang-Fu Chang, Liann-Be Lai, Chao-Sung |
| Copyright Year | 2020 |
| Description | A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO3) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP/anti-CRP interaction. The CRP/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 μg/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 μg/mL to 1 mg/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases. |
| Starting Page | 6640 |
| e-ISSN | 14248220 |
| DOI | 10.3390/s20226640 |
| Journal | Sensors |
| Issue Number | 22 |
| Volume Number | 20 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-11-19 |
| Access Restriction | Open |
| Subject Keyword | Sensors Telecommunications Surface Acoustic Wave C-reactive Protein Piezoelectric Lithium Niobate |
| Content Type | Text |
| Resource Type | Article |
