NDLI: The Emerging Role of CD24 in Cancer Theranostics—A Novel Target for Fluorescence Image-Guided Surgery in Ovarian Cancer and Beyond

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The Emerging Role of CD24 in Cancer Theranostics—A Novel Target for Fluorescence Image-Guided Surgery in Ovarian Cancer and Beyond

Content Provider	MDPI
Author	Line, Bjørge Kleinmanns, Katrin Fosse, Vibeke McCormack, Emmet
Copyright Year	2020
Description	Complete cytoreductive surgery is the cornerstone of the treatment of epithelial ovarian cancer (EOC). The application of fluorescence image-guided surgery (FIGS) allows for the increased intraoperative visualization and delineation of malignant lesions by using fluorescently labeled targeting biomarkers, thereby improving intraoperative guidance. CD24, a small glycophosphatidylinositol-anchored cell surface receptor, is overexpressed in approximately 70% of solid cancers, and has been proposed as a prognostic and therapeutic tumor-specific biomarker for EOC. Recently, preclinical studies have demonstrated the benefit of CD24-targeted contrast agents for non-invasive fluorescence imaging, as well as improved tumor resection by employing CD24-targeted FIGS in orthotopic patient-derived xenograft models of EOC. The successful detection of miniscule metastases denotes CD24 as a promising biomarker for the application of fluorescence-guided surgery in EOC patients. The aim of this review is to present the clinical and preclinically evaluated biomarkers for ovarian cancer FIGS, highlight the strengths of CD24, and propose a future bimodal approach combining CD24-targeted fluorescence imaging with radionuclide detection and targeted therapy.
Starting Page	255
e-ISSN	20754426
DOI	10.3390/jpm10040255
Journal	Journal of Personalized Medicine
Issue Number	4
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2020-11-27
Access Restriction	Open
Subject Keyword	Journal of Personalized Medicine Oncology Biomarker Intraoperative Imaging Debulking Surgery Complete Resection Epithelial Ovarian Cancer Optical Imaging Cd24
Content Type	Text
Resource Type	Article

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