NDLI: Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films as Antibacterial Wound Dressing

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Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films as Antibacterial Wound Dressing

Content Provider	MDPI
Author	Alzarea, Abdulaziz I. Alruwaili, Nabil K. Ahmad, Muhammad Masood Munir, Muhammad Usman Butt, Adeel Masood Alrowaili, Ziyad A. Shahari, Muhammad Syafiq Bin Almalki, Ziyad S. Alqahtani, Saad S. Dolzhenko, Anton V. Ahmad, Naveed
Copyright Year	2022
Description	Biopolymer-based antibacterial films are attractive materials for wound dressing application because they possess chemical, mechanical, exudate absorption, drug delivery, antibacterial, and biocompatible properties required to support wound healing. Herein, we fabricated and characterized films composed of arabinoxylan (AX) and sodium alginate (SA) loaded with gentamicin sulfate (GS) for application as a wound dressing. The FTIR, XRD, and thermal analyses show that AX, SA, and GS interacted through hydrogen bonding and were thermally stable. The AXSA film displays desirable wound dressing characteristics: transparency, uniform thickness, smooth surface morphology, tensile strength similar to human skin, mild water/exudate uptake capacity, water transmission rate suitable for wound dressing, and excellent cytocompatibility. In Franz diffusion release studies, >80% GS was released from AXSA films in two phases in 24 h following the Fickian diffusion mechanism. In disk diffusion assay, the AXSA films demonstrated excellent antibacterial effect against E.coli, S. aureus, and P. aeruginosa. Overall, the findings suggest that GS-loaded AXSA films hold potential for further development as antibacterial wound dressing material.
Starting Page	2899
e-ISSN	14220067
DOI	10.3390/ijms23052899
Journal	International Journal of Molecular Sciences
Issue Number	5
Volume Number	23
Language	English
Publisher	MDPI
Publisher Date	2022-03-07
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Arabinoxylan Sodium Alginate Wound Healing Antibacterial Dressing Drug Delivery
Content Type	Text
Resource Type	Article

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