Loading...
Please wait, while we are loading the content...
Effects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repair
| Content Provider | MDPI |
|---|---|
| Author | Abdul, Latif Hamzé Rui, Seabra Ferreira Júnior Renata, Maria De Camargo Eugênio Reis, Carlos Henrique Bertoni Buchaim, Rogerio Leone Pomini, Karina Torres Zattiti, Isabella Vasconcelos Duarte, Marco Antonio Hungaro Alcalde, Murilo Priori Barraviera, Benedito Pontes, Fenelon Martinho Lima Grandini, Carlos Roberto Ortiz, Adriana De Cássia Fideles, Simone Ortiz Moura Junior, Geraldo Marco Rosa Teixeira, Daniel De Bortoli Pereira, Eliana De Souza Bastos Mazuqueli Pilon, João Paulo Galletti Miglino, Maria Angelica Buchaim, Daniela Vieira |
| Copyright Year | 2022 |
| Abstract | There are several treatment methods available for bone repair, although the effectiveness becomes limited in cases of large defects. The objective of this pre-clinical protocol was to evaluate the grafting of hydroxyapatite/tricalcium phosphate (BCP) ceramic biomaterial (B; QualyBone BCP®, QualyLive, Amadora, Portugal) together with the heterologous fibrin biopolymer (FB; CEVAP/UNESP Botucatu, Brazil) and with photobiomodulation (PBM; Laserpulse®, Ibramed, Amparo, Brazil) in the repair process of bone defects. Fifty-six rats were randomly divided into four groups of seven animals each: the biomaterial group (G1/B), the biomaterial plus FB group (G2/BFB); the biomaterial plus PBM group (G3/B + PBM), and the biomaterial plus FB plus PBM group (G4/BFB + PBM). After anesthesia, a critical defect was performed in the center of the rats’ parietal bones, then filled and treated according to their respective groups. The rats were euthanized at 14 and 42 postoperative days. Histomorphologically, at 42 days, the G4/BFB + PBM group showed a more advanced maturation transition, with more organized and mature bone areas forming concentric lamellae. A birefringence analysis of collagen fibers also showed a more advanced degree of maturation for the G4/BFB + PBM group. In the comparison between the groups, in the two experimental periods (14 and 42 days), in relation to the percentage of formation of new bone tissue, a significant difference was found between all groups (G1/B (5.42 ± 1.12; 21.49 ± 4.74), G2/BFB (5.00 ± 0.94; 21.77 ± 2.83), G3/B + PBM (12.65 ± 1.78; 29.29 ± 2.93), and G4/BFB + PBM (12.65 ± 2.32; 31.38 ± 2.89)). It was concluded that the use of PBM with low-level laser therapy (LLLT) positively interfered in the repair process of bone defects previously filled with the biocomplex formed by the heterologous fibrin biopolymer associated with the synthetic ceramic of hydroxyapatite and tricalcium phosphate. |
| Starting Page | 2075 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym14102075 |
| Journal | Polymers |
| Issue Number | 10 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-05-19 |
| Access Restriction | Open |
| Subject Keyword | Polymers Cell Tissue Engineering Dentistry and Oral Surgery Bone Regeneration Bone Repair Biomaterials Fibrin Tissue Adhesive Fibrin Low-level Laser Therapy Photobiomodulation |
| Content Type | Text |
| Resource Type | Article |
