NDLI: Angiogenesis in Chronic Inflammatory Skin Disorders

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Angiogenesis in Chronic Inflammatory Skin Disorders

Content Provider	MDPI
Author	Lee, Hyun Ji Hong, Yong Jun Kim, Miri
Copyright Year	2021
Description	Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) have recently been added to an important angiogenic factor. Accumulating evidence indicates associations between angiogenesis and chronic inflammatory skin diseases. Angiogenesis is deeply involved in the pathogenesis of psoriasis. VEGF, angiopoietins, tumor necrosis factor-a, interleukin-8, and interleukin-17 are unregulated in psoriasis and induce angiogenesis. Angiogenesis may be involved in the pathogenesis of atopic dermatitis, and in particular, mast cells are a major source of VEGF expression. Angiogenesis is an essential process in rosacea, which is induced by LL-37 from a signal cascade by microorganisms, VEGF, and MMP-3 from mast cells. In addition, angiogenesis by increased VEGF has been reported in chronic urticaria and hidradenitis suppurativa. The finding that VEGF is expressed in inflammatory skin lesions indicates that inhibition of angiogenesis is a useful strategy for treatment of chronic, inflammatory skin disorders.
Starting Page	12035
e-ISSN	14220067
DOI	10.3390/ijms222112035
Journal	International Journal of Molecular Sciences
Issue Number	21
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-11-07
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Dermatology Angiogenesis Psoriasis Atopic Dermatitis Rosacea Chronic Urticaria Hidradenitis Suppurativa
Content Type	Text
Resource Type	Article

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