NDLI: Digital Cognitive Biomarker for Mild Cognitive Impairments and Dementia: A Systematic Review

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Digital Cognitive Biomarker for Mild Cognitive Impairments and Dementia: A Systematic Review

Content Provider	MDPI
Author	Ding, Zihan Lee, Tsz-Lok Chan, Agnes S.
Copyright Year	2022
Description	The dementia population is increasing as the world’s population is growing older. The current systematic review aims to identify digital cognitive biomarkers from computerized tests for detecting dementia and its risk state of mild cognitive impairment (MCI), and to evaluate the diagnostic performance of digital cognitive biomarkers. A literature search was performed in three databases, and supplemented by a Google search for names of previously identified computerized tests. Computerized tests were categorized into five types, including memory tests, test batteries, other single/multiple cognitive tests, handwriting/drawing tests, and daily living tasks and serious games. Results showed that 78 studies were eligible. Around 90% of the included studies were rated as high quality based on the Newcastle–Ottawa Scale (NOS). Most of the digital cognitive biomarkers achieved comparable or even better diagnostic performance than traditional paper-and-pencil tests. Moderate to large group differences were consistently observed in cognitive outcomes related to memory and executive functions, as well as some novel outcomes measured by handwriting/drawing tests, daily living tasks, and serious games. These outcomes have the potential to be sensitive digital cognitive biomarkers for MCI and dementia. Therefore, digital cognitive biomarkers can be a sensitive and promising clinical tool for detecting MCI and dementia.
Starting Page	4191
e-ISSN	20770383
DOI	10.3390/jcm11144191
Journal	Journal of clinical medicine
Issue Number	14
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-07-19
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Medical Informatics Digital Biomarker Digital Cognitive Biomarker Computerized Test Digital Cognitive Test Dementia Mild Cognitive Impairment Systematic Review
Content Type	Text
Resource Type	Article

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