NDLI: Exosomes as A Next-Generation Diagnostic and Therapeutic Tool in Prostate Cancer

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Exosomes as A Next-Generation Diagnostic and Therapeutic Tool in Prostate Cancer

Content Provider	MDPI
Author	Gaglani, Simita Gonzalez-Kozlova, Edgar Lundon, Dara J. Tewari, Ashutosh K. Dogra, Navneet Kyprianou, Natasha
Copyright Year	2021
Description	Extracellular vesicles (EVs) have brought great momentum to the non-invasive liquid biopsy procedure for the detection, characterization, and monitoring of cancer. Despite the common use of PSA (prostate-specific antigen) as a biomarker for prostate cancer, there is an unmet need for a more specific diagnostic tool to detect tumor progression and recurrence. Exosomes, which are EVs that are released from all cells, play a large role in physiology and pathology, including cancer. They are involved in intercellular communication, immune function, and they are present in every bodily fluid studied—making them an excellent window into how cells are operating. With liquid biopsy, EVs can be isolated and analyzed, enabling an insight into a potential therapeutic value, serving as a vehicle for drugs or nucleic acids that have anti-neoplastic effects. The current application of advanced technology also points to higher-sensitivity detection methods that are minimally invasive. In this review, we discuss the current understanding of the significance of exosomes in prostate cancer and the potential diagnostic value of these EVs in disease progression.
Starting Page	10131
e-ISSN	14220067
DOI	10.3390/ijms221810131
Journal	International Journal of Molecular Sciences
Issue Number	18
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-09-20
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Urology and Nephrology Prostate Cancer Psa Extracellular Vesicles Exosomes Biomarkers Liquid Biopsy Therapeutic Resistance
Content Type	Text
Resource Type	Article

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