NDLI: Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise

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Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise

Content Provider	MDPI
Author	Nyborg, Christoffer Melsom, Helene Bonnevie-Svendsen, Martin Melau, Jørgen Seljeflot, Ingebjørg Hisdal, Jonny
Copyright Year	2021
Description	We assessed endothelial function by flow-mediated dilatation (FMD), levels of the NO-precursor L-arginine, and markers of endothelial inflammation before, at the finish line, and one week after the Norseman Xtreme triathlon. The race is an Ironman distance triathlon with a total elevation of 5200 m. Nine male participants were included. They completed the race in 14.5 (13.4–15.3) h. FMD was significantly reduced to 3.1 (2.1–5.0)% dilatation compared to 8.7 (8.2–9.3)% dilatation before the race (p < 0.05) and was normalized one week after the race. L-arginine showed significantly reduced levels at the finish line (p < 0.05) but was normalized one week after the race. Markers of endothelial inflammation E-Selectin, VCAM-1, and ICAM-1 all showed a pattern with increased values at the finish line compared to before the race (all p < 0.05), with normalization one week after the race. In conclusion, we found acutely reduced FMD with reduced L-arginine levels and increased E-Selectin, VCAM-1, and ICAM-1 immediately after the Norseman Xtreme triathlon. Our findings indicate a transient reduced endothelial function, measured by the FMD-response, after prolonged strenuous exercise that could be explained by reduced NO-precursor L-arginine levels and increased endothelial inflammation.
Starting Page	86
e-ISSN	20754663
DOI	10.3390/sports9060086
Journal	Sports
Issue Number	6
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2021-06-17
Access Restriction	Open
Subject Keyword	Sports Sport Sciences Fmd Endothelium Inflammation Ironman Triathlon E-selectin Vcam-1 Icam-1 L-arginine
Content Type	Text
Resource Type	Article

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