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Review of Recent Advances in Lipid Analysis of Biological Samples via Ambient Ionization Mass Spectrometry
| Content Provider | MDPI |
|---|---|
| Author | Lu, Haiyan Zhang, Hua Xu, Shuling Li, Lingjun |
| Copyright Year | 2021 |
| Description | The rapid and direct structural characterization of lipids proves to be critical for studying the functional roles of lipids in many biological processes. Among numerous analytical techniques, ambient ionization mass spectrometry (AIMS) allows for a direct molecular characterization of lipids from various complex biological samples with no/minimal sample pretreatment. Over the recent years, researchers have expanded the applications of the AIMS techniques to lipid structural elucidation via a combination with a series of derivatization strategies (e.g., the Paternò–Büchi (PB) reaction, ozone-induced dissociation (OzID), and epoxidation reaction), including carbon–carbon double bond (C=C) locations and sn-positions isomers. Herein, this review summarizes the reaction mechanisms of various derivatization strategies for C=C bond analysis, typical instrumental setup, and applications of AIMS in the structural elucidation of lipids from various biological samples (e.g., tissues, cells, and biofluids). In addition, future directions of AIMS for lipid structural elucidation are discussed. |
| Starting Page | 781 |
| e-ISSN | 22181989 |
| DOI | 10.3390/metabo11110781 |
| Journal | Metabolites |
| Issue Number | 11 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-11-15 |
| Access Restriction | Open |
| Subject Keyword | Metabolites Analytical Chemistry Lipidomics Structural Elucidation Ambient Ionization Mass Spectrometry Biological Samples |
| Content Type | Text |
| Resource Type | Article |
