NDLI: Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos (Dasypus novemcinctus) Reveal Population Structure and Admixture in the Amazon Basin

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Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos (Dasypus novemcinctus) Reveal Population Structure and Admixture in the Amazon Basin

Content Provider	MDPI
Author	Bernardo, Tenório Bagagli, Eduardo Matute, Daniel Garces, Hans Garces, Adalberto Alves, Lucas Yamauchi, Danielle Hrycyk, Marluce Barker, Bridget Teixeira, Marcus
Copyright Year	2021
Description	Paracoccidioidomycosis is an endemic fungal disease to Latin America caused by at least five species-level genotypes of Paracoccidioides, named P. lutzii, P. brasiliensis (S1a and S1b populations), P. americana, P. restrepiensis, and P. venezuelensis. In this manuscript, we report on Paracoccidioides sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of seven Paracoccidioides isolates and used phylogenomics and populations genetics for genotyping. We found that P. brasiliensis and P. lutzii are both present in the Amazon region. Additionally, we identified two Paracoccidioides isolates that seem to be the result of admixture between divergent populations within P. brasiliensis sensu stricto. Both of these isolates were recovered from armadillos in a P. lutzii endemic area in Midwestern Brazil. Additionally, two isolates from human patients also show evidence of resulting from admixture. Our results suggest that the populations of P. brasiliensis sensu stricto exchange genes in nature. More generally, they suggest that population structure and admixture within species is an important source of variation for pathogenic fungi.
Starting Page	54
e-ISSN	2309608X
DOI	10.3390/jof7010054
Journal	Journal of Fungi
Issue Number	1
Volume Number	7
Language	English
Publisher	MDPI
Publisher Date	2021-01-15
Access Restriction	Open
Subject Keyword	Journal of Fungi Mycology Paracoccidioides Amazon Armadillos Paracoccidioidomycosis Admixture
Content Type	Text
Resource Type	Article

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