NDLI: Triterpenes and Phenolic Compounds from Euphorbia deightonii with Antiviral Activity against Herpes Simplex Virus Type-2

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Triterpenes and Phenolic Compounds from Euphorbia deightonii with Antiviral Activity against Herpes Simplex Virus Type-2

Content Provider MDPI
Author Norbert, Kúsz Katalin, Burián Vágvölgyi, Máté Kókai, Dávid Rédei, Dóra Saidu, Muhammad Bello Tsai, Yu-Chi Berkecz, Róbert Hohmann, Judit
Copyright Year 2022
Description Two undescribed compounds, 3β,7β-dihydroxy-24-methylenelanosta-8-ene-11-one (1) and neolignane deightonin (4) were isolated from the aerial parts of Euphorbia deightonii Croizat together with six known compounds, namely, kansenone (2), euphorbol-7-one (3), dehydrodiconiferyl diacetate (5), marylaurencinol D (6), scoparon (7), and 3,4,3′-tri-O-methylellagic acid (8). The structures of the isolated compounds were determined by HRESIMS, 1D $(^{1}$H,$ ^{13}$C JMOD) and 2D NMR (HSQC, HMBC,$ ^{1}H–^{1}$H COSY, NOESY) spectroscopic analysis, and by comparison of the assignments with literature data. The anti-herpes simplex virus type-2 activity of the isolated compounds were investigated by qRT-PCR assay on Vero cells after determining cytotoxic concentration 50% $(CC_{50}$). Compounds 1, 3, 4, and 7 exhibited inhibitory effects with respective $IC_{50}$ values of 7.05, 2.42, 11.73, and 0.032 µM. Scoparon (7) showed the strongest anti-HSV activity with a selectivity index of 10.93.
Starting Page 764
e-ISSN 22237747
DOI 10.3390/plants11060764
Journal Plants
Issue Number 6
Volume Number 11
Language English
Publisher MDPI
Publisher Date 2022-03-13
Access Restriction Open
Subject Keyword Plants Integrative and Complementary Medicine Euphorbia Deightonii Euphorbiaceae Triterpenes Neolignans Coumarin Trimethyl-ellagic Acid
Content Type Text
Resource Type Article

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Triterpenes and Phenolic Compounds from Euphorbia deightonii with Antiviral Activity against Herpes Simplex Virus Type-2

Content Provider	MDPI
Author	Norbert, Kúsz Katalin, Burián Vágvölgyi, Máté Kókai, Dávid Rédei, Dóra Saidu, Muhammad Bello Tsai, Yu-Chi Berkecz, Róbert Hohmann, Judit
Copyright Year	2022
Description	Two undescribed compounds, 3β,7β-dihydroxy-24-methylenelanosta-8-ene-11-one (1) and neolignane deightonin (4) were isolated from the aerial parts of Euphorbia deightonii Croizat together with six known compounds, namely, kansenone (2), euphorbol-7-one (3), dehydrodiconiferyl diacetate (5), marylaurencinol D (6), scoparon (7), and 3,4,3′-tri-O-methylellagic acid (8). The structures of the isolated compounds were determined by HRESIMS, 1D $(^{1}$H,$ ^{13}$C JMOD) and 2D NMR (HSQC, HMBC,$ ^{1}H–^{1}$H COSY, NOESY) spectroscopic analysis, and by comparison of the assignments with literature data. The anti-herpes simplex virus type-2 activity of the isolated compounds were investigated by qRT-PCR assay on Vero cells after determining cytotoxic concentration 50% $(CC_{50}$). Compounds 1, 3, 4, and 7 exhibited inhibitory effects with respective $IC_{50}$ values of 7.05, 2.42, 11.73, and 0.032 µM. Scoparon (7) showed the strongest anti-HSV activity with a selectivity index of 10.93.
Starting Page	764
e-ISSN	22237747
DOI	10.3390/plants11060764
Journal	Plants
Issue Number	6
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-03-13
Access Restriction	Open
Subject Keyword	Plants Integrative and Complementary Medicine Euphorbia Deightonii Euphorbiaceae Triterpenes Neolignans Coumarin Trimethyl-ellagic Acid
Content Type	Text
Resource Type	Article

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