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Efficacy of a Polyphenolic, Standardized Green Tea Extract for the Treatment of COVID-19 Syndrome: A Proof-of-Principle Study
| Content Provider | MDPI |
|---|---|
| Author | Bettuzzi, Saverio Gabba, Luigi Cataldo, Simona |
| Copyright Year | 2021 |
| Description | The lack of therapies for moderate COVID-19 syndrome prompted us to use a standardized polyphenolic green tea extract rich in catechins during the lockdown due to the pandemic in Italy (Autumn 2020). Catechins are powerful antioxidant, anti-inflammatory and antiviral agents that are safe for human use. While awaiting hospitalization, 10 swab-positive patients, symptomatic for SARS-COV-2, were treated for 15 days at home with two sessions of inhalation plus three capsules per day (total catechins: 840 mg; total EGCG: 595 mg). All patients recovered fully and had no symptoms at a median of 9 days, with a range of 7–15 days. Seven switched to a negative SARS-COV-2 nasopharyngeal swab test at a median of 9 days, with a range of 6–13 days. Among the 3 patients still swab-positive, one had a strong decrease of infection down to a “very low” SARS-COV-2 nucleic acid load at 5 days. All patients exited quarantine at the end of therapy because they were free of symptoms. Inflammation markers α-1 anti-trypsin, C-reactive protein and eosinophils had significantly decreased. The IL-6 and erythrocyte sedimentation rate decreased in 7 out of 10 patients. To the best of our knowledge, this is the first report of the efficacy of green tea catechin against COVID-19 syndrome. These results may open new perspectives in the fight against the disease. |
| e-ISSN | 26738112 |
| DOI | 10.3390/covid1010002 |
| Journal | COVID |
| Issue Number | 1 |
| Volume Number | 1 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-05-31 |
| Access Restriction | Open |
| Subject Keyword | COVID Covid Integrative and Complementary Medicine Antioxidant Antiviral Catechin Covid-19 Cytokine Storm Egcg Green Tea Il-6 Inflammation Polyphenols Sars-cov-2 Theaphenon E |
| Content Type | Text |
| Resource Type | Article |
