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Stereocomplexation of Poly(Lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels
| Content Provider | MDPI |
|---|---|
| Author | Wang, Zhidan Wu, Jie Shi, Xiaoyu Song, Fei Gao, Wenli Liu, Shouxin |
| Copyright Year | 2020 |
| Description | Physical crosslinking and chemical crosslinking were used to further improve the mechanical properties and stability of the gel. A temperature/pH dual sensitive and double-crosslinked gel was prepared by the stereo-complex of HEMA-PLLA20 and HEMA-PDLA20 as a physical crosslinking agent, ethylene glycol dimethacrylate (EGDMA) as a chemical crosslinking agent, and azodiisobutyronitrile (AIBN) as an initiator for free radical polymerization. This paper focused on the performance comparison of chemical crosslinked gel, a physical crosslinked gel, and a dual crosslinked gel. The water absorption, temperature, and pH sensitivity of the three hydrogels were studied by a scanning electron microscope (SEM) and swelling performance research. We used a thermal analysis system (TGA) and dynamic viscoelastic spectrometer to study thermal properties and mechanical properties of these gels. Lastly, the in vitro drug release behavior of double-crosslinked hydrogel loaded with doxorubicin under different conditions was studied. The results show that the double-crosslinked and temperature/pH dual responsive hydrogels has great mechanical properties and good stability. |
| Starting Page | 2204 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym12102204 |
| Journal | Polymers |
| Issue Number | 10 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-09-25 |
| Access Restriction | Open |
| Subject Keyword | Polymers Coatings and Films Polymer Science Double-crosslinked Polylactic Acid Temperature/ph Sensitive Stereo-complexation |
| Content Type | Text |
| Resource Type | Article |
