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Exploring New Drug Targets for Type 2 Diabetes: Success, Challenges and Opportunities
| Content Provider | MDPI |
|---|---|
| Author | Kanwal, Abhinav Kanwar, Navjot Bharati, Sanjay Srivastava, Prateek Singh, Shailendra P. Amar, Salomon |
| Copyright Year | 2022 |
| Description | There are substantial shortcomings in the drugs currently available for treatment of type 2 diabetes mellitus. The global diabetic crisis has not abated despite the introduction of new types of drugs and targets. Persistent unaddressed patient needs remain a significant factor in the quest for new leads in routine studies. Drug discovery methods in this area have followed developments in the market, contributing to a recent rise in the number of molecules. Nevertheless, troubling developments and fresh challenges are still evident. Recently, metformin, the most widely used first-line drug for diabetes, was found to contain a carcinogenic contaminant known as N-nitroso dimethylamine (NDMA). Therefore, purity and toxicity are also a big challenge for drug discovery and development. Moreover, newer drug classes against SGLT-2 illustrate both progress and difficulties. The same was true previously in the case of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Furthermore, researchers must study the importance of mechanistic characteristics of novel compounds, as well as exposure-related hazardous aspects of current and newly identified protein targets, in order to identify new pharmacological molecules with improved selectivity and specificity. |
| Starting Page | 331 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines10020331 |
| Journal | Biomedicines |
| Issue Number | 2 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-31 |
| Access Restriction | Open |
| Subject Keyword | Biomedicines Type 2 Diabetes Diabetes Mellitus Drug Development Drug Discovery Lead Molecules New Targets |
| Content Type | Text |
| Resource Type | Article |
