NDLI: Incidence of Antibiotic Treatment Failure in Patients with Nursing Home-Acquired Pneumonia and Community Acquired Pneumonia

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Incidence of Antibiotic Treatment Failure in Patients with Nursing Home-Acquired Pneumonia and Community Acquired Pneumonia

Content Provider	MDPI
Author	Jo, ão Gonçalves Lopes, Mariana Silva, Gonçalo Alves Nogueira, Rui Marado, Daniela Athayde, Carlos Silva, Dilva Figueiredo, Ana Fortuna, Jorge Carvalho, Armando
Copyright Year	2021
Description	Purpose: Nursing home-acquired pneumonia (NHAP) patients are at higher risk of multi-drug resistant infection (MDR) than those with community-acquired pneumonia (CAP). Recent evidence suggests a single risk factor for MDR does not accurately predict the need for broad-spectrum antibiotics. The goal of this study was to compare the rate antibiotic failure between NHAP and CAP patients. Methods: Demographic characteristics, co-morbidities, clinical and laboratory variables, antibiotic therapy, and mortality data were collected retrospectively for all patients with pneumonia admitted to an Internal Medicine Service between April 2017 and April 2018. Results: In total, 313 of 556 patients had CAP and 243 had NHAP. NHAP patients were older, and were more likely to be dependent, to have recent antibiotic use, and to experience treatment failure (odds ratio (OR) 1.583; 95% CI 1.102–2.276; p = 0.013). In multivariate analysis, patient’s origin did not predict treatment failure (OR 1.083; 95% CI 0.726–1.616; p = 0.696). Discussion: Higher rates of antibiotic failure and mortality in NHAP patients were explained by the presence of other risk factors such as comorbidities, more severe presentation, and age. Admission from a nursing home is not a sufficient condition to start broader-spectrum antibiotics.
Ending Page	44
Page Count	12
Starting Page	33
e-ISSN	20367449
DOI	10.3390/idr13010006
Journal	Infectious Disease reports
Issue Number	1
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-01-05
Access Restriction	Open
Subject Keyword	Infectious Disease reports Infectious Disease Reports Gerontology Nursing Home-acquired Pneumonia Community-acquired Pneumonia Antimicrobial Drug Resistance Epidemiology Treatment Failure
Content Type	Text
Resource Type	Article

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