NDLI: Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy)

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Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy)

Content Provider	MDPI
Author	Barbalace, Maria Zallocco, Lorenzo Beghelli, Daniela Ronci, Maurizio Scortichini, Serena Digiacomo, Maria Macchia, Marco Mazzoni, Maria Fiorini, Dennis Lucacchini, Antonio Hrelia, Silvana Giusti, Laura Angeloni, Cristina
Copyright Year	2021
Description	Neurodegenerative diseases are driven by several mechanisms such as inflammation, abnormal protein aggregation, excitotoxicity, mitochondrial dysfunction and oxidative stress. So far, no therapeutic strategies are available for neurodegenerative diseases and in recent years the research is focusing on bioactive molecules present in food. In particular, extra-virgin olive oil (EVOO) phenols have been associated to neuroprotection. In this study, we investigated the potential antioxidant and neuroprotective activity of two different EVOO extracts obtained from Quercetano cultivar trees grown in two different areas (plain and hill) of the Tuscany region (Italy). The different geographical origin of the orchards influenced phenol composition. Plain extract presented a higher content of phenyl ethyl alcohols, cinnammic acids, oleacein, oleocanthal and flavones; meanwhile, hill extract was richer in lignans. Hill extract was more effective in protecting differentiated SH-SY5Y cells from peroxide stress thanks to a marked upregulation of the antioxidant enzymes heme oxygenase 1, NADPH quinone oxidoreductase 1, thioredoxin Reductase 1 and glutathione reductase. Proteomic analysis revealed that hill extract plays a role in the regulation of proteins involved in neuronal plasticity and activation of neurotrophic factors such as BDNF. In conclusion, these data demonstrate that EVOOs can have important neuroprotective activities, but these effects are strictly related to their specific phenol composition.
Starting Page	421
e-ISSN	20763921
DOI	10.3390/antiox10030421
Journal	Antioxidants
Issue Number	3
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-03-10
Access Restriction	Open
Subject Keyword	Antioxidants Biochemical Research Olive Oil Oxidative Stress Phenols Neuroprotection Neurotrophins Proteomics
Content Type	Text
Resource Type	Article

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