NDLI: Mannose Receptor-Mediated Carbon Nanotubes as an Antigen Delivery System to Enhance Immune Response Both In Vitro and In Vivo

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Mannose Receptor-Mediated Carbon Nanotubes as an Antigen Delivery System to Enhance Immune Response Both In Vitro and In Vivo

Content Provider	MDPI
Author	Feng, Haibo Feng, Yangyang Lin, Lang Wu, Daiyan Liu, Qianqian Li, Hangyu Zhang, Xinnan Li, Sheng Tang, Feng Liu, Ziwei Zhang, Linzi
Copyright Year	2022
Description	Carbon nanotubes (CNTs) are carbon allotropes consisting of one, two, or more concentric rolled graphene layers. These can intrinsically regulate immunity by activating the innate immune system. Mannose receptors (MR), a subgroup of the C-type lectin superfamily, are abundantly expressed on macrophages and dendritic cells. These play a crucial role in identifying pathogens, presenting antigens, and maintaining internal environmental stability. Utilizing the specific recognition between mannose and antigen-presenting cells (APC) surface mannose receptors, the antigen-carrying capacity of mannose-modified CNTs can be improved. Accordingly, here, we synthesized the mannose-modified carbon nanotubes (M-MWCNT) and evaluated them as an antigen delivery system through a series of in vitro and in vivo experiments. In vitro, M-MWCNT carrying large amounts of OVA were rapidly phagocytized by macrophages and promoted macrophage proliferation to facilitate cytokines (IL-1β, IL-6) secretion. In vivo, in mice, M-MWCNT induced the maturation of dendritic cells and increased the levels of antigen-specific antibodies (IgG, IgG1, IgG2a, IgG2b), and cytokines (IFN-γ, IL-6). Taken together, M-MWCNT could induce both humoral and cellular immune responses and thereby can be utilized as an efficient antigen-targeted delivery system.
Starting Page	4239
e-ISSN	14220067
DOI	10.3390/ijms23084239
Journal	International Journal of Molecular Sciences
Issue Number	8
Volume Number	23
Language	English
Publisher	MDPI
Publisher Date	2022-04-11
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Immunology Mannose Receptors Mannose-modified Carbon Nanotubes Antigen Delivery System Immune Response
Content Type	Text
Resource Type	Article

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