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Association of Mitochondrial DNA Copy Number and Telomere Length with Prevalent and Incident Cancer and Cancer Mortality in Women: A Prospective Swedish Population-Based Study
| Content Provider | MDPI |
|---|---|
| Author | Li, Yanni Sundquist, Kristina Wang, Xiao Zhang, Nai Qi Hedelius, Anna Sundquist, Jan Memon, Ashfaque |
| Copyright Year | 2021 |
| Description | Changes in mitochondrial DNA copy number (mtDNA-CN) and telomere length have, separately, been proposed as risk factors for various cancer types. However, those results are conflicting. Here, mtDNA-CN and relative telomere length were measured in 3225 middle-aged women included in a large population-based prospective cohort. The baseline mtDNA-CN in patients with prevalent breast cancer was significantly higher (12.39 copies/µL) than cancer-free individuals. During an average of 15.2 years of follow-up, 520 patients were diagnosed with cancer. Lower mtDNA-CN was associated with decreased risk of genital organ cancer (hazard ratio (HR), 0.84), and shorter telomere length was associated with increased risk of urinary system cancer (HR, 1.79). Furthermore, mtDNA-CN was inversely associated with all-cause (HR, 1.20) and cancer-specific mortality (HR, 1.21) when considering all cancer types. Surprisingly, shorter telomere length was associated with decreased risk of cancer-specific mortality when considering all cancer types (HR, 0.85). Finally, lower mtDNA-CN and shorter telomere length were associated with increased risk of both all-cause and cancer-specific mortality in genital organ cancer patients. In this study population, we found that mtDNA-CN and telomere length were significantly associated with prevalent and incident cancer and cancer mortality. However, these associations were cancer type specific and need further investigation. |
| Starting Page | 3842 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13153842 |
| Journal | Cancers |
| Issue Number | 15 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-30 |
| Access Restriction | Open |
| Subject Keyword | Cancers Oncology Mitochondrial Dna Copy Number Relative Telomere Length Cancer Types Prevalent Cancer Cancer Risk Mortality |
| Content Type | Text |
| Resource Type | Article |
