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Elevated Levels of CTRP1 in Obesity Contribute to Tumor Progression in a p53-Dependent Manner
| Content Provider | MDPI |
|---|---|
| Author | Park, Rackhyun Jang, Minsu Park, Yea-In Park, Yeonjeong Namkoong, Sim Lee, Jin Park, Junsoo |
| Copyright Year | 2021 |
| Description | Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression. |
| Starting Page | 3619 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13143619 |
| Journal | Cancers |
| Issue Number | 14 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-19 |
| Access Restriction | Open |
| Subject Keyword | Cancers Oncology Ctrp1 Obesity P53 Cancer Adiponectin |
| Content Type | Text |
| Resource Type | Article |
