NDLI: Impact of Treating Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Prospective Cohort Study

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Impact of Treating Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Prospective Cohort Study

Content Provider	MDPI
Author	Sara, Fontserè Carmen, Infante-Domínguez Alejandro, Suárez-Benjumea Marta, Suñer-Poblet Carmen, González-Corvillo Guillermo, Martín-Gutiérrez Jer, ónimo Pachón Mar, ía Pachón-Ibáñez Bernal, Gabriel Cordero, Elisa
Copyright Year	2021
Description	This study aims to define the epidemiologic, clinical, and microbiological features of asymptomatic bacteriuria (AB) and cystitis in kidney transplantation recipients (KTRs), and to determine the impact of antimicrobial therapy of AB and the risk factors of cystitis. We conducted a prospective observational study of AB and cystitis in KTRs from January to June 2017. One-hundred ninety seven KTRs were included: 175 (88.8%) with AB and 22 (11.2%) with cystitis. The most frequent etiologies were Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and Pseudomonas aeruginosa. No differences were observed regarding the etiologies, antimicrobial susceptibility patterns, and microbiologic outcomes in AB vs. cystitis. The treatment of AB diminished the microbiological cure and increased the rates of microbiologic relapses and reinfections; in addition, treated AB patients showed a trend of developing symptomatic urinary tract infection in the following six months. The analysis of the data identified the following independent risk factors for cystitis during the six months of follow-up: AB treatment, thymoglobulin induction, previous acute pyelonephritis, and time since transplantation < 1 year. In summary, considering the lack of clinical benefits of treating AB and its impact on cystitis development in the follow-up, we support the recommendation of not screening for or treating AB.
Starting Page	218
e-ISSN	20796382
DOI	10.3390/antibiotics10020218
Journal	Antibiotics
Issue Number	2
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-02-22
Access Restriction	Open
Subject Keyword	Antibiotics Transplantation Urinary Tract Infections Kidney Recipients Asymptomatic Bacteriuria Cystitis Prospective Observational Cohort
Content Type	Text
Resource Type	Article

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