NDLI: Next-Generation Sequencing-Directed Therapy in Patients with Metastatic Breast Cancer in Routine Clinical Practice

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Next-Generation Sequencing-Directed Therapy in Patients with Metastatic Breast Cancer in Routine Clinical Practice

Content Provider	MDPI
Author	Anna, Rüland Bruzas, Simona Kuemmel, Sherko Harrach, Hakima Breit, Elisabeth Ataseven, Beyhan Traut, Alexander Kostara, Athina Chiari, Ouafaa Dittmer-Grabowski, Christine Reinisch, Mattea
Copyright Year	2021
Description	Next-generation sequencing (NGS) followed by matched therapy has opened up new therapeutic options to patients with metastatic breast cancer (mBC). Here we report our experience with this approach in everyday clinical practice. This retrospective study included 95 patients with mBC who were genotyped with the $FoundationOne^{®}$ (CDx) assay in a commercial molecular pathology laboratory. Genetic alterations were identified in all tumor specimens, and 83 patients (87.4%) had a median of 2 (range, 1–6) potentially actionable alterations. A multidisciplinary tumor board recommended genomically guided therapy to 63 patients, 30 of whom received such treatment. Everolimus (n = 15) and anti-human epidermal growth factor receptor 2 (HER2) therapy (n = 6) were most frequently administered. The ratio of progression-free survival (PFS) under NGS-based therapy to PFS under the last line of standard therapy prior to NGS was >1.3 in 13 (43.3%) patients, indicative of a clinical benefit to NGS-directed therapy. One-year overall survival rates were 22.7% (95% CI, 6.5–44.4) in 65 patients allocated to the standard therapy versus 62.9% (95% CI, 41.6–78.2) in 30 patients receiving the matched therapy. In conclusion, NGS-matched treatment improved the clinical outcomes in a subgroup of mBC patients.
Starting Page	4564
e-ISSN	20726694
DOI	10.3390/cancers13184564
Journal	Cancers
Issue Number	18
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-09-11
Access Restriction	Open
Subject Keyword	Cancers Oncology Breast Cancer Metastatic Next-generation Sequencing Ngs Molecular Profiling Targeted Therapy Precision Medicine
Content Type	Text
Resource Type	Article

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