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Polyphenolic and Methylxanthine Bioaccessibility of Cocoa Bean Shell Functional Biscuits: Metabolomics Approach and Intestinal Permeability through Caco-2 Cell Models
| Content Provider | MDPI |
|---|---|
| Author | Caroline, Stévigny Rojo-Poveda, Olga Barbosa-Pereira, Letricia Khattabi, Charaf El Youl, Estelle N. H. Bertolino, Marta Delporte, Cédric Pochet, Stéphanie |
| Copyright Year | 2020 |
| Description | Cocoa bean shell (CBS), a by-product with considerable concentrations of bioactive compounds and proven biofunctional potential, has been demonstrated to be a suitable ingredient for high-fiber functional biscuits adapted to diabetic consumers. In this work, the in vitro bioaccessibility and intestinal absorption of polyphenols and methylxanthines contained in these biscuits were evaluated, and the effect of the food matrix was studied. Biscuits containing CBS and the CBS alone underwent in vitro digestion followed by an intestinal permeability study. The results confirmed that compounds were less bioavailable in the presence of a food matrix, although the digestion contributed to their release from this matrix, increasing the concentrations available at the intestinal level and making them capable of promoting antioxidant and antidiabetic activities. After digestion, CBS biscuits were shown to possess α-glucosidase inhibition capacity comparable to that of acarbose. Moreover, the presence of the food matrix improved the stability of polyphenols throughout the digestion process. Intestinal absorption of flavan-3-ols seemed to be limited to a maximum threshold and was therefore independent of the sample, while procyanidin was not absorbed. Methylxanthine absorption was high and was boosted by the presence of the food matrix. The results confirmed the biofunctional potential of CBS-based biscuits. |
| Starting Page | 1164 |
| e-ISSN | 20763921 |
| DOI | 10.3390/antiox9111164 |
| Journal | Antioxidants |
| Issue Number | 11 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-11-22 |
| Access Restriction | Open |
| Subject Keyword | Antioxidants Biochemical Research Cocoa Bean Shell Biscuits Functional Foods Polyphenols Methylxanthines in Vitro Digestion Α-glucosidase Inhibition Bioaccessibility Metabolomics Caco-2 Absorption |
| Content Type | Text |
| Resource Type | Article |
