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Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies
| Content Provider | MDPI |
|---|---|
| Author | Pham, Thao Shields, Mario Spaulding, Christina Principe, Daniel Li, Bo Underwood, Patrick Trevino, Jose Bentrem, David Munshi, Hidayatullah |
| Copyright Year | 2021 |
| Description | The advent of immunotherapy has transformed the treatment landscape for several human malignancies. Antibodies against immune checkpoints, such as anti-PD-1/PD-L1 and anti-CTLA-4, demonstrate durable clinical benefits in several cancer types. However, checkpoint blockade has failed to elicit effective anti-tumor responses in pancreatic ductal adenocarcinoma (PDAC), which remains one of the most lethal malignancies with a dismal prognosis. As a result, there are significant efforts to identify novel immune-based combination regimens for PDAC, which are typically first tested in preclinical models. Here, we discuss the utility and limitations of syngeneic and genetically-engineered mouse models that are currently available for testing immunotherapy regimens. We also discuss patient-derived xenograft mouse models, human PDAC organoids, and ex vivo slice cultures of human PDAC tumors that can complement murine models for a more comprehensive approach to predict response and resistance to immunotherapy regimens. |
| Starting Page | 440 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13030440 |
| Journal | Cancers |
| Issue Number | 3 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-25 |
| Access Restriction | Open |
| Subject Keyword | Cancers Oncology Immunotherapy Pancreatic Cancer Murine Models Genetically-engineered Mouse Models Patient-derived Xenografts Organoids Human Tumor Slice Cultures |
| Content Type | Text |
| Resource Type | Article |
