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Ameliorating Effect on Aβ-Induced Alzheimer's Mice by Litsea cubeba Persoon Powder
| Content Provider | MDPI |
|---|---|
| Author | Lee, Kuan-Tseng Chu, Chen-Yeon Chiang, Shen-Shih |
| Copyright Year | 2021 |
| Description | Alzheimer’s disease (AD) is caused by excessive oxidative damage and aging. The objective of this study was to investigate the anti-dementia effect of LCP fruit powder on amyloid β (Aβ)-induced Alzheimer’s mice. The composition of LCP essential oil was determined by gas chromatography/mass spectrometry. In addition, the water maze was used to evaluate the learning and memorizing abilities of the mice. The concentrations of malondialdehyde (MDA), protein carbonyl, phosphorylated τ-protein, and the deposition of Aβ plaques in mouse brains were also assessed. The results showed that the main components of essential oils in LCP and d-limonene, neral, and geranial contents were 14.15%, 30.94%, and 31.74%, respectively. Furthermore, oral administration with different dosages of LCP significantly decreased the escape time (21.25~33.62 s) and distance (3.23~5.07 m) in the reference memory test, and increased the duration time (26.14~28.90 s) and crossing frequency (7.00~7.88 times) in the target zone of probe test (p < 0.05). LCP also inhibited the contents of MDA and the phosphor-τ-protein from oxidative stress, reduced the brain atrophy by about 3~8%, and decreased the percentage of Aβ plaques from 0.44 to 0.05%. Finally, it was observed that the minimum dosage of LCP fruit powder (LLCP, 30.2 mg/day) could prevent oxidative stress induced by Aβ and subsequently facilitate memory and learning deficits in Aβ-induced neurotoxicity and cognitively impaired mice. |
| Starting Page | 5709 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26185709 |
| Journal | Molecules |
| Issue Number | 18 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-21 |
| Access Restriction | Open |
| Subject Keyword | Molecules Gerontology Alzheimer's Disease Amyloid Β Protein Litsea Cubeba Persoon Neurotoxicity Cognitive Impairment |
| Content Type | Text |
| Resource Type | Article |
