Loading...
Please wait, while we are loading the content...
Could Iron-Nitrogen Doping Modulate the Cytotoxicity of $TiO_{2}$ Nanoparticles?
| Content Provider | MDPI |
|---|---|
| Author | Nica, Ionela Cristina Miu, Bogdan Andrei Stan, Miruna S. Diamandescu, Lucian Dinischiotu, Anca |
| Copyright Year | 2022 |
| Description | Titanium dioxide nanoparticles $(TiO_{2}$ NPs) are found in several products on the market that include paints, smart textiles, cosmetics and food products. Besides these, $TiO_{2}$ NPs are intensively researched for their use in biomedicine, agriculture or installations to produce energy. Taking into account that several risks have been associated with the use of $TiO_{2}$ NPs, our aim was to provide $TiO_{2}$ NPs with improved qualities and lower toxicity to humans and the environment. Pure $TiO_{2}$ P25 NPs and the same NPs co-doped with iron (1%) and nitrogen atoms (P25-Fe(1%)-N NPs) by hydrothermal treatment to increase the photocatalytic activity in the visible light spectrum were in vitro evaluated in the presence of human lung cells. After 24 and 72 h of incubation, the oxidative stress was initiated in a time- and dose-dependent manner with major differences between pure P25 and P25-Fe(1%)-N NPs as revealed by malondialdehyde and reactive oxygen species levels. Additionally, a lower dynamic of autophagic vacuoles formation was observed in cells exposed to Fe-N-doped P25 NPs compared to the pure ones. Therefore, our results suggest that Fe-N doping of $TiO_{2}$ NPs can represent a valuable alternative to the conventional P25 Degussa particles in industrial and medical applications. |
| Starting Page | 770 |
| e-ISSN | 20794991 |
| DOI | 10.3390/nano12050770 |
| Journal | Nanomaterials |
| Issue Number | 5 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-02-25 |
| Access Restriction | Open |
| Subject Keyword | Nanomaterials Toxicology Titanium Dioxide P25 Degussa Nanoparticles Iron Doping Photocatalysts Human Cytotoxicity |
| Content Type | Text |
| Resource Type | Article |
