NDLI: Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis

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Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis

Content Provider	MDPI
Author	de Lima, Marcos Antonio Pereira Silva, Álife Diêgo Lima Filho, Antônio Carlos Silva Do Nascimento Cordeiro, Thiago Lima Bezerra, João Pedro De Souza Rocha, Maria Aline Barroso Pinheiro, Sally De França Lacerda Junior, Roberto Flávio Fontenelle Pinheiro Gadelha, Maria Do Socorro Vieira Silva, Cláudio Gleidiston Lima da
Copyright Year	2021
Description	Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV with laryngeal carcinoma. The search was carried out in two databases, Scopus and PubMed, using the following terms: “Epstein-Barr virus” and “laryngeal carcinoma”. A total of 187 records were found, of which 31 were selected for meeting the inclusion and exclusion criteria. The meta-analysis yielded an overall pooled prevalence of 43.72% (95% confidence interval (CI): 34.35–53.08). Studies carried out in Europe and Eurasia had slightly higher pooled prevalence than other subgroups, while the prevalence of studies performed in developed countries was higher than in developing countries (46.37% vs. 34.02%). Furthermore, laryngeal carcinoma occurred almost three times as often among EBV-infected individuals compared to those without EBV infection (odds ratio = 2.86 (95% CI: 1.18–6.90); Begg’s test, p = 0.843 and Egger’s test, p = 0.866). Our findings support the idea that EBV is related to laryngeal carcinoma. However, further studies are needed before recognizing a definitive etiological role of EBV in the development and/or progression of laryngeal carcinomas.
Starting Page	1429
e-ISSN	20760817
DOI	10.3390/pathogens10111429
Journal	Pathogens
Issue Number	11
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-11-04
Access Restriction	Open
Subject Keyword	Pathogens Infectious Diseases Epstein-barr Virus (ebv) Laryngeal Carcinoma Carcinogenesis Oncovirus
Content Type	Text
Resource Type	Article

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