NDLI: Sperm Selection for ICSI: Do We Have a Winner?

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Sperm Selection for ICSI: Do We Have a Winner?

Content Provider	MDPI
Author	Baldini, Domenico Ferri, Daniele Baldini, Giorgio Maria Lot, Dario Catino, Assunta Vizziello, Damiano Vizziello, Giovanni
Copyright Year	2021
Description	In assisted reproductive technology (ART), the aim of sperm cells’ preparation is to select competent spermatozoa with the highest fertilization potential and in this context, the intracytoplasmic sperm injection (ICSI) represents the most applied technique for fertilization. This makes the process of identifying the perfect spermatozoa extremely important. A number of methods have now been developed to mimic some of the natural selection processes that exist in the female reproductive tract. Although many studies have been conducted to identify the election technique, many doubts and disagreements still remain. In this review, we will discuss all the sperm cell selection techniques currently available for ICSI, starting from the most basic methodologies and continuing with those techniques suitable for sperm cells with reduced motility. Furthermore, different techniques that exploit some sperm membrane characteristics and the most advanced strategy for sperm selection based on microfluidics, will be examined. Finally, a new sperm selection method based on a micro swim-up directly on the ICSI dish will be analyzed. Eventually, advantages and disadvantages of each technique will be debated, trying to draw reasonable conclusions on their efficacy in order to establish the gold standard method.
Starting Page	3566
e-ISSN	20734409
DOI	10.3390/cells10123566
Journal	Cells
Issue Number	12
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-12-17
Access Restriction	Open
Subject Keyword	Cells Obstetrics and Gynecology Reproductive Biology Assisted Reproductive Technology (art) in Vitro Fertilization (ivf) Intracytoplasmic Sperm Injection (icsi) Sperm Selection Density Gradient (dgc) Swim-up (su) Horizontal Sperm Migration Microfluidic
Content Type	Text
Resource Type	Article

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