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Genetic Modifications to Alter Blood Pressure Level
| Content Provider | MDPI |
|---|---|
| Author | Ohara, Hiroki Nabika, Toru |
| Copyright Year | 2022 |
| Description | Genetic manipulation is one of the indispensable techniques to examine gene functions both in vitro and in vivo. In particular, cardiovascular phenotypes such as blood pressure cannot be evaluated in vitro system, necessitating the creation of transgenic or gene-targeted knock-out and knock-in experimental animals to understand the pathophysiological roles of specific genes on the disease conditions. Although genome-wide association studies (GWAS) in various human populations have identified multiple genetic variations associated with increased risk for hypertension and/or its complications, the causal links remain unresolved. Genome-editing technologies can be applied to many different types of cells and organisms for creation of knock-out/knock-in models. In the post-GWAS era, it may be more worthwhile to validate pathophysiological implications of the risk variants and/or candidate genes by creating genome-edited organisms. |
| Starting Page | 1855 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines10081855 |
| Journal | Biomedicines |
| Issue Number | 8 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-01 |
| Access Restriction | Open |
| Subject Keyword | Biomedicines Peripheral Vascular Disease Knock-out Genome-editing Shr Shrsp Dahl Ss |
| Content Type | Text |
| Resource Type | Article |
