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Gestational Diabetes Mellitus in Pregnant Women with Beta-Thalassemia Minor: A Matched Case-Control Study
| Content Provider | MDPI |
|---|---|
| Author | Falcone, Veronica Heinzl, Florian Itariu, Bianca Karla Reischer, Theresa Muin, Dana Anaïs Pateisky, Petra Foessleitner, Philipp Ott, Johannes Farr, Alex Rosta, Klara |
| Copyright Year | 2022 |
| Description | Pregnancy in women with thalassemia minor is considered safe. However, a higher incidence of maternal and neonatal complications in women with the disorder has been reported in the literature. This study aimed to determine whether there is an increased risk of gestational diabetes mellitus (GDM) in pregnant women with beta-thalassemia minor. We conducted a retrospective matched case-control study of 230 pregnant women who delivered at the Department of Obstetrics and Feto-Maternal Medicine at the Medical University of Vienna between the years 2008 and 2020, whereof 115 women had beta-thalassemia minor. We found no significant difference in the occurrence of GDM between the case group and control group of age and BMI-matched healthy women. However, we observed a significantly lower hemoglobin (Hb) and hematocrit (Ht) level during the first, the second, and the third trimesters of pregnancy, and postpartum (all: p < 0.001) among women with beta-thalassemia minor compared to the healthy controls. Neonates of women with beta-thalassemia were more likely to experience post-natal jaundice and excessive weight loss (p < 0.001). We conclude that GDM is not more likely to occur in pregnant women with beta-thalassemia minor. However, clinicians should be made aware of the risk of adverse maternal and neonatal outcomes. Furthermore, women with beta-thalassemia minor should undergo regular laboratory screening and multidisciplinary pregnancy care. |
| Starting Page | 2050 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm11072050 |
| Journal | Journal of clinical medicine |
| Issue Number | 7 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-06 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Womens Studies Beta-thalassemia Diabetes Gestational Pregnancy High-risk Pregnancy Complications Anemia Hypochromic |
| Content Type | Text |
| Resource Type | Article |
