NDLI: Zizania latifolia and Its Major Compound Tricin Regulate Immune Responses in OVA-Treated Mice

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Zizania latifolia and Its Major Compound Tricin Regulate Immune Responses in OVA-Treated Mice

Content Provider	MDPI
Author	Lee, Jae-Yeul Park, Se-Ho Jhee, Kwang-Hwan Yang, Seun-Ah
Copyright Year	2022
Description	Tricin, a flavone belonging to the Gramineae family, has been confirmed to be the primary compound in a Zizania latifolia extract (ZLE) that prevents allergies. Various allergic reactions occur because of the unbalanced differentiation of T help cells (Th) and the consequent overproduction of IgE. Therefore, the regulation of Th1 and Th2 responses by T helper cell differentiation is essential for suppressing allergic responses. This study confirmed the immunomodulatory effects of ZLE and the major compound tricin in an OVA-sensitized mouse model. The IgE and OVA-specific production of tricin and ZLE in plasma were investigated in OVA-sensitized mice. The effects of tricin and ZLE on the amount of Th1 and Th2 cytokines and transcription factors released in splenocytes were investigated in OVA-sensitized mice. The skin roughness and the number of mast cells were confirmed by staining the skin surface with H&E and toluidine blue. Tricin and ZLE reduced the plasma IgE and OVA-specific-IgE levels significantly compared to the OVA group. On the other hand, tricin and ZLE promoted the release of the Th1 cytokines IL-12 and IFN-γ and inhibited the release of Th2 cytokines (IL-4, -10, -13, and -5) in OVA-sensitized mice. Tricin and ZLE induced T-bet and NFATc2 expression, and-down regulated GATA-3 levels. The skin roughness and the number of mast cells decreased in the OVA-immunized mice. Overall, the data indicate that tricin and ZLE may prevent allergy-related diseases through immunomodulation.
Starting Page	3978
e-ISSN	14203049
DOI	10.3390/molecules27133978
Journal	Molecules
Issue Number	13
Volume Number	27
Language	English
Publisher	MDPI
Publisher Date	2022-06-21
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Flavonoids Tricin Zizania Latifolia Extract Anti-allergic Activity Immunomodulation
Content Type	Text
Resource Type	Article

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