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Influence of Antihypertensive Treatment on RAAS Peptides in Newly Diagnosed Hypertensive Patients
| Content Provider | MDPI |
|---|---|
| Author | Stephan, Krähenbühl Vischer, Annina Kuster, Gabriela Twerenbold, Raphael Pfister, Otmar Zhou, Qian Villiger, Andrea Poglitsch, Marko Mayr, Michael Osswald, Stefan Haschke, Manuel Burkard, Thilo |
| Copyright Year | 2021 |
| Description | (1) Background: Recently, influences of antihypertensive treatment on the renin–angiotensin–aldosterone system (RAAS) has gained attention, regarding a possible influence on inflammatory and anti-inflammatory pathways. We aimed to study the effects of newly initiated antihypertensive drugs on angiotensin (Ang) II and Ang (1–7) as representers of two counter-regulatory axes. (2) Methods: In this randomized, open-label trial investigating RAAS peptides after the initiation of perindopril, olmesartan, amlodipine, or hydrochlorothiazide, Ang II and Ang (1–7) equilibrium concentrations were measured at 8 a.m. and 12 a.m. at baseline and after four weeks of treatment. Eighty patients were randomized (1:1:1:1 fashion). (3) Results: Between the four substances, we found significant differences regarding the concentrations of Ang II (p < 0.0005 for 8 a.m., 12 a.m.) and Ang (1–7) (p = 0.019 for 8 a.m., p = 0.002), and increased by olmesartan (p < 0.0005), amlodipine (p = 0.012), and hydrochlorothiazide (p = 0.001). Ang (1–7) was increased by perindopril and olmesartan (p = 0.008/0.002), but not measurably altered by amlodipine and hydrochlorothiazide (p = 0.317/ 0.109). (4) Conclusion: The initiation of all first line antihypertensive treatments causes early and distinct alterations of equilibrium angiotensin levels. Given the additional AT1R blocking action of olmesartan, RAAS peptides shift upon initiation of perindopril and olmesartan appear to work in favor of the anti-inflammatory axis compared to amlodipine and hydrochlorothiazide. |
| Starting Page | 534 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells10030534 |
| Journal | Cells |
| Issue Number | 3 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-03 |
| Access Restriction | Open |
| Subject Keyword | Cells Peripheral Vascular Disease Arterial Hypertension Renin–angiotensin–aldosterone System Antihypertensive Drug Angiotensin-converting-enzyme Inhibitor Angiotensin Receptor Antagonist Calcium Channel Blocker Thiazide Diuretic |
| Content Type | Text |
| Resource Type | Article |
