NDLI: Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega

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Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega

Content Provider	MDPI
Author	Addie, Diane Covell-Ritchie, Johanna Jarrett, Oswald Fosbery, Mark
Copyright Year	2020
Description	This is the first report of a successful treatment of a non-effusive feline infectious peritonitis (FIP) uveitis case using an oral adenosine nucleoside analogue drug and feline interferon omega, and alpha-1 acid glycoprotein (AGP) as an indicator of recovery. A 2-year-old male neutered Norwegian Forest Cat presented with uveitis, keratic precipitates, mesenteric lymphadenopathy and weight loss. The cat was hypergammaglobulinaemic and had a non-regenerative anaemia. Feline coronavirus (FCoV) RNA was detected in a mesenteric lymph node fine-needle aspirate by a reverse-transcriptase polymerase chain reaction—non-effusive FIP was diagnosed. Prednisolone acetate eye drops were administered three times daily for 2 weeks. Oral adenosine nucleoside analogue (Mutian) treatment started. Within 50 days of Mutian treatment, the cat had gained over one kilogram in weight, his globulin level reduced from 77 to 51 g/L and his haematocrit increased from 22 to 35%; his uveitis resolved and his sight improved. Serum AGP level reduced from 3100 to 400 μg/mL (within normal limits). Symmetric dimethylarginine (SDMA) was above normal at 28 μg/dL, reducing to 14 μg/dL on the cessation of treatment; whether the SDMA increase was due to FIP lesions in the kidney or Mutian is unknown. Mutian treatment stopped and low-dose oral recombinant feline interferon omega begun—the cat’s recovery continued.
Starting Page	1216
e-ISSN	19994915
DOI	10.3390/v12111216
Journal	Viruses
Issue Number	11
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2020-10-27
Access Restriction	Open
Subject Keyword	Viruses Tropical Medicine Feline Infectious Peritonitis Coronavirus Uveitis Mutian Adenosine Nucleoside Analogue Feline Interferon Omega Mesenteric Lymph Node Alpha-1 Acid Glycoprotein Symmetric Dimethylarginine
Content Type	Text
Resource Type	Article

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