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The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity
| Content Provider | MDPI |
|---|---|
| Author | Tan, Jinyan Cheng, Yangang Wang, Shihui Li, Jianli Ren, Haiqin Qiao, Yuanbiao Li, Qingshan Wang, Yingli |
| Copyright Year | 2022 |
| Description | In our current investigation, 37 constituents (1–37), including 11 megastigmanes (1–11), 17 flavonoids (12–28) and 9 phenylpropanoids (29–37), were isolated from a 70%-EtOH extract of Diaphragma juglandis Fructus. Among them, compounds 1–3, 12 and 29 were new compounds and their structures were elucidated on the basis of physicochemical evidence and meticulous spectroscopic analysis (NMR, HRESIMS and CD). Compounds 13, 16, 21 and 28 showed moderate inhibitory effect on α-glycosidase inhibitory activities, with $IC_{50}$ values being in the range of 29.47–54.82 µM and stronger than the positive control (acarbose, 60.01 ± 4.82 µM). |
| Starting Page | 3045 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27103045 |
| Journal | Molecules |
| Issue Number | 10 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-05-10 |
| Access Restriction | Open |
| Subject Keyword | Molecules Toxicology Walnut Megastigmanes Bicyclic Neomegastigmane Flavonoids Phenylpropanoids Α-glucosidase Inhibition Activity |
| Content Type | Text |
| Resource Type | Article |
