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Females and Males Show Differences in Early-Stage Transcriptomic Biomarkers of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma
| Content Provider | MDPI |
|---|---|
| Author | Liu, Quewang Wang, Yueying Duan, Meiyu Fan, Yusi Pan, Xingyuan Liu, Shuai Yu, Qiong Huang, Lan Zhou, Fengfeng |
| Copyright Year | 2021 |
| Description | The incidence and mortality rates of lung cancers are different between females and males. Therefore, sex information should be an important part of how to train and optimize a diagnostic model. However, most of the existing studies do not fully utilize this information. This study carried out a comparative investigation between sex-specific models and sex-independent models. Three feature selection algorithms and five classifiers were utilized to evaluate the contribution of the sex information to the detection of early-stage lung cancers. Both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) showed that the sex-specific models outperformed the sex-independent detection of early-stage lung cancers. The Venn plots suggested that females and males shared only a few transcriptomic biomarkers of early-stage lung cancers. Our experimental data suggested that sex information should be included in optimizing disease diagnosis models. |
| Starting Page | 347 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics11020347 |
| Journal | Diagnostics |
| Issue Number | 2 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-02-19 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Biochemical Research Sex Disparity Early Stage Transcriptomic Biomarker Luad Lusc |
| Content Type | Text |
| Resource Type | Article |
