Loading...
Please wait, while we are loading the content...
Similar Documents
New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities
| Content Provider | MDPI |
|---|---|
| Author | Shin, Hee-Jae Anh, Cao-Van Cho, Duk-Yeon Choi, Dong-Kug Kang, Jong-Soon Trinh, Phan Choi, Byeoung-Kyu Lee, Hwa-Sun |
| Copyright Year | 2021 |
| Description | Three new polyene compounds, talacyanols A–C (1–3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1–5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher’s methods, as well as comparison with previously reported literature data. All the compounds (1–5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI50 values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines. |
| Starting Page | 836 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26040836 |
| Journal | Molecules |
| Issue Number | 4 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-02-05 |
| Access Restriction | Open |
| Subject Keyword | Molecules Mycology Talaromyces Cyanescens Marine-derived Fungus Polyenes Cytotoxicity Anti-neuroinflammatory |
| Content Type | Text |
| Resource Type | Article |
