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Protein-Mediated Transformations of Superparamagnetic Nanoparticles Evidenced by Single-Particle Inductively Coupled Plasma Tandem Mass Spectrometry: A Disaggregation Phenomenon
| Content Provider | MDPI |
|---|---|
| Author | Agnieszka, Kamińska Sikorski, Jacek Matczuk, Magdalena Kruszewska, Joanna Trzaskowski, Maciej Timerbaev, Andrei R. Jarosz, Maciej |
| Copyright Year | 2022 |
| Description | Progress toward translating superparamagnetic iron oxide nanoparticles (SPIONs) with specific diagnostic and therapeutic properties for clinical applications depends on developing and implementing appropriate methodologies that would allow in-depth characterizations of their behavior in a real biological environment. Herein, we report a versatile approach for studying interactions between SPIONs and proteins using single-particle inductively coupled plasma tandem mass spectrometry. By monitoring the changes in the size distribution upon exposure to human serum, the formation of stable protein corona is revealed, accompanied by particle disaggregation. |
| Starting Page | 1088 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms23031088 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 3 |
| Volume Number | 23 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-19 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Superparamagnetic Iron Oxide Nanoparticles Human Serum Single-particle Inductively Coupled Plasma Tandem Mass Spectrometry |
| Content Type | Text |
| Resource Type | Article |
