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Local and Systemic Adverse Reactions to mRNA COVID-19 Vaccines Comparing Two Vaccine Types and Occurrence of Previous COVID-19 Infection
| Content Provider | MDPI |
|---|---|
| Author | Oleguer, Parés-Badell Xavier, Martínez-Gómez Laia, Pinós Jos, é Ángel Rodrigo-Pendás Ant, ònia Agustí Borras-Bermejo, Blanca Uriona, Sonia Otero-Romero, Susana Cossio-Gil, Yolima Aguilera, Cristina Campins, Magda |
| Copyright Year | 2021 |
| Description | The aim of this study was to assess adverse reactions to COVID-19 vaccines, comparing the BNT162b2 or the mRNA-1273 COVID-19 vaccines and the presence and seriousness of a previous COVID-19 infection. We conducted a cross-sectional online survey of vaccinated healthcare workers at a tertiary hospital in Barcelona (Spain). Thirty-eight percent of vaccine recipients responded to the questionnaire. We compared the prevalence of adverse reactions by vaccine type and history of COVID-19 infections. A total of 2373 respondents had received the BNT162b2 vaccine, and 506 the mRNA-1273 vaccine. The prevalence of at least one adverse reaction with doses 1 and 2 was 41% and 70%, respectively, in the BNT162b2 group, and 60% and 92% in the mRNA-1273 group (p < 0.001). The BNT162b2 group reported less prevalence of all adverse reactions. Need for medical leave was significantly more frequent among the mRNA-1273 group (12% versus 4.6% p < 0.001). Interestingly, respondents with a history of allergies or chronic illnesses did not report more adverse reactions. The frequency of adverse reactions with dose 2 was 96% (95% CI 88–100%) for those with a history of COVID-19 related hospitalization, and 86% (95% CI 83–89%) for those with mild or moderate symptomatic COVID-19, significantly higher than for participants with no history of COVID-19 infections (67%, 95% CI 65–69%). Our results could help inform vaccine recipients of the probability of their having adverse reactions to COVID-19 vaccines. |
| Starting Page | 1463 |
| e-ISSN | 2076393X |
| DOI | 10.3390/vaccines9121463 |
| Journal | Vaccines |
| Issue Number | 12 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-10 |
| Access Restriction | Open |
| Subject Keyword | Vaccines Infectious Diseases Sars-cov-2 Covid-19-vaccination Mrna Vaccines Adverse Reactions Healthcare Workers |
| Content Type | Text |
| Resource Type | Article |
